Pseudovirus deep mutatioinal scanning of HA from A/Anhui/1/2013 (H7N9) for entry and binding to tufted duck MHC-II
Analysis by Dadonaite et al (2026)
See https://github.com/dms-vep/Flu-H7-Anhui13-MHCII-binding for full code.
Documentation of results rendered as of Wed Jul 22 14:54:23 2026
Barcode to codon-variant lookup table
Data files
Count barcodes for variants
Analysis notebooks
Data files
Barcode count CSVs (click triangle to expand/collapse)
Functional effects of mutations
Final summary plots
Interactive plots of average mutation functional effects (click triangle to expand/collapse)
Interactive plots of average mutation functional effects from single-mutant variants only (click triangle to expand/collapse)
Interactive plots of differences in functional effects between conditions (click triangle to expand/collapse)
Analysis notebooks
- Analysis of functional scores
Notebooks with per-selection global epistasis fitting (click triangle to expand/collapse)
Notebooks averaging mutation functional effects (click triangle to expand/collapse)
Notebooks taking differences in functional effects between conditions (click triangle to expand/collapse)
Data files
Per-variant functional score CSVs (click triangle to expand/collapse)
Per-selection mutation functional effect CSVs (click triangle to expand/collapse)
Average mutation functional effects (CSV files) (click triangle to expand/collapse)
Average mutation functional effects from single-mutant variants only (CSV files) (click triangle to expand/collapse)
Average mutation latent-phenotype effects (CSV files) (click triangle to expand/collapse)
Differences in functional effects (CSV files) (click triangle to expand/collapse)
MHCII binding
Final summary plots
MHCII binding mutation effect plots (click triangle to expand/collapse)
Analysis notebooks
Fits of polyclonal models to individual MHCII binding selections (click triangle to expand/collapse)
Average selections for MHCII binding (click triangle to expand/collapse)
Data files
Probability (fraction) escape for each variant in each MHCII binding selection (CSVs) (click triangle to expand/collapse)
MHCII binding CSVs (click triangle to expand/collapse)
Integrated summary plots
entry all cells
tufted duck MHCII binding
Wrapped heatmaps
Heatmap HTMLs
Compare entry among cells
Final plots
Analysis notebooks
Data files
dms-viz visualizations
dms-viz JSON files
Notebooks prepping dms-viz JSONs
Additional files
HA site numbering