Deep mutational scanning of H5N1 influenza haemagglutinin using a barcoded lentiviral platform (strain A/American Wigeon/South Carolina/USDA-000345-001/2021)

Analysis by Dadonaite et al (2024)

See https://github.com/dms-vep/Flu_H5_American-Wigeon_South-Carolina_2021-H5N1_DMS for full code.

Contents

Barcode to codon-variant lookup table

Analysis notebooks

Data files

Count barcodes for variants

Analysis notebooks

Data files

Functional effects of mutations

Final summary plots

Analysis notebooks

Data files

Antibody/serum escape

Final summary plots

Analysis notebooks

Data files

stability

Final summary plots

Analysis notebooks

Data files

Integrated summary plots

phenotypes

all sera escape

VRC antibody escape

mRNA vaccine mouse sera escape

cattle sera escape

Crowe antibody escape

Additional files

HA site numbering

Cell entry effect comparison

Functional effect distribution

Visualizations of DMS data on protein structure (dms-viz JSONs)