Deep mutational scanning using HIV Envelopes TRO11 and BF520 to identify mutations that escape neutralization by antibody 007 and other V3-targeting antibodies
Analysis by Caelan Radford and Jesse Bloom (2025)
See https://github.com/dms-vep/HIV_Envelope_TRO11_DMS_007 for full code.
Barcode to codon-variant lookup table
Analysis notebooks
Data files
Count barcodes for variants
Analysis notebooks
Data files
Barcode count CSVs (click triangle to expand/collapse)
Antibody/serum escape
Final summary plots
antibody escape mutation effect plots (click triangle to expand/collapse)
Analysis notebooks
Fits of polyclonal models to individual antibody escape selections (click triangle to expand/collapse)
Average selections for antibody escape (click triangle to expand/collapse)
Data files
Probability (fraction) escape for each variant in each antibody escape selection (CSVs) (click triangle to expand/collapse)
antibody escape CSVs (click triangle to expand/collapse)
Integrated summary plots
all antibodies and cell entry
Additional analysis-specific files