Deep mutational scanning of the F protein from RSV Long strain
Analysis by Simonich et al (2026)
See https://github.com/dms-vep/RSV_Long_F_DMS for full code.
Documentation of results rendered as of Thu Feb 12 19:33:50 2026
Barcode to codon-variant lookup table
Analysis notebooks
Data files
Count barcodes for variants
Analysis notebooks
Data files
Barcode count CSVs (click triangle to expand/collapse)
Functional effects of mutations
Final summary plots
Interactive plots of average mutation functional effects (click triangle to expand/collapse)
Interactive plots of average mutation functional effects from single-mutant variants only (click triangle to expand/collapse)
Analysis notebooks
- Analysis of functional scores
Notebooks with per-selection global epistasis fitting (click triangle to expand/collapse)
Notebooks averaging mutation functional effects (click triangle to expand/collapse)
Data files
Per-variant functional score CSVs (click triangle to expand/collapse)
Per-selection mutation functional effect CSVs (click triangle to expand/collapse)
Average mutation functional effects (CSV files) (click triangle to expand/collapse)
Average mutation functional effects from single-mutant variants only (CSV files) (click triangle to expand/collapse)
Average mutation latent-phenotype effects (CSV files) (click triangle to expand/collapse)
Antibody/serum escape
Final summary plots
antibody escape mutation effect plots (click triangle to expand/collapse)
Analysis notebooks
Fits of polyclonal models to individual antibody escape selections (click triangle to expand/collapse)
Average selections for antibody escape (click triangle to expand/collapse)
Data files
Probability (fraction) escape for each variant in each antibody escape selection (CSVs) (click triangle to expand/collapse)
antibody escape CSVs (click triangle to expand/collapse)
Integrated summary plots
cell entry
all antibodies
Nirsevimab
Clesrovimab
Nirsevimab-and-Clesrovimab
Palivizumab
RSM01
Suptavumab
dms-viz visualizations
dms-viz JSON files
Notebooks prepping dms-viz JSONs
Row-wrapped heatmaps
Heatmap HTMLs
Sequence variation analysis
Sequence variations with effects CSVs
Interactive sequence variation plots
Sequence variation analysis notebooks