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Effects of mutations to spike of SARS-CoV-2 BA.2 on spike-mediated cell entry and ACE2 binding as measured in pseudotyped lentiviral deep mutational scanning experiments

This is is an interactive chart. Mouseover points for details and measurements, and use the top zoom bar to zoom in on specific sites. The heatmaps show the effects of mutations on functions of the protein, and the sliders let you filter for mutations with some minimal functional effect.

Analysis by Dadonaite et al, bioRxiv, DOI 10.1101/2023.11.13.566961 (2023).

See https://github.com/dms-vep/SARS-CoV-2_Omicron_BA.2_spike_ACE2_affinity for code/data.