Interactive plot of shifts in effects of mutations. Negative values indicate mutations that have shifted to become more deleterious; positive values indicate mutations shifted to be more beneficial.
Use the site zoom bar at the top to zoom in on specific sites. The line plot shows a summary statistic indicating the effects of mutations at each site. The heat map shows the effects of individual mutations, with parental amino-acid identities indicated by x and gray indicating non-measured mutations.
You can mouse over points to get details about individual measurements, including measurements in individual comparisons.
The options at the bottom of the plot let you modify the display, such as by selecting how many different variants a mutation must be seen in to be shown ( minimum times_seen ), how many different experimental comparisons the mutation was measured in ( minimum n_comparisons ), what site summary statistic to show, etc.
Analysis by Dadonaite et al, bioRxiv, DOI 10.1101/2023.11.13.566961 (2023).
See https://github.com/dms-vep/SARS-CoV-2_XBB.1.5_spike_DMS for code/data.