Comparison of natural HCoV-229E diversity to cell entry effects in the RBD binding loops.
We compared the natural amino-acid variation of HCoV-229E spike to the measured effects of mutations on cell entry in the RBD binding loops. For further exploration:
Site-wise Amino Acid Diversity of Natural Sequences of HCoV-229E
- The black bars represent the effective number of amino acids at each site, calculated from Shannon entropy.
- The bar at the top indicate major spike domains: NTD, RBD, and S2.
- The loop labels (L1, L2, L3) mark the three receptor-binding loops within the RBD.
- Hover over bars to see the exact effective number of amino acids, amino acid richness, and domain assignment for each site.
Click on the expansion box in the upper right of the plot to enlarge for easier viewing, or click here to open the plot in a stand-alone window.
RBD binding loops cell entry effcets
- The three panels show Loop 1 (308-325), Loop 2 (352-359), and Loop 3 (404-408) side by side for easy comparison.
- The X marks indicate the 1984 strain amino acid identity at each position.
- Hover over any cell to see the exact site, wildtype amino acid, mutant amino acid, and quantitative cell entry effect.
click here for a standalone link: