Effects of mutations on antibody neutralization
Study by Caleb Carr, Kate Crawford, et al. The study is available here.
Effects of mutations to Lassa Josiah strain glycoprotein on antibody neutralization
Plot below shows how mutations to Lassa Josiah strain glycoprotein affect antibody neutralization.
These are interactive charts. Mouseover points for details and measurements, and use the top zoom bar to zoom in on specific sites. The options at the bottom let you apply or alter a variety of filters and viewing options, such as choosing the site summary metric, only showing escape for sites with some minimal functional effect, or choosing whether to floor the functional effects or escape at zero.
The line plots at top of each plot show the effects of mutations at each site, and the heatmaps show the effects of individual mutations on cell entry or immune escape.
Analysis by Carr et al., bioRxiv, DOI https://doi.org/10.1101/2024.02.05.579020 (2024).
See https://github.com/dms-vep/LASV_Josiah_GP_DMS for code/data.