Antibody Escape
We determined the effects of receptor binding protein mutations on antibody neutralization. Antibody selections were performed by incubating pseudovirus libraries with different concentrations of antibody, followed by infection of CHO cells expressing bat ephrin-B3. Neutralization curves were fit on the DMS data with polyclonal.
In total, we measured the effects of receptor binding protein mutations for six different antibodies that target three different epitopes.
Individual Antibody Selections
Individual antibody selection model fitting notebooks
Average Antibody Escape
Averaging antibody escape across libraries and replicate selections.
Antibody Escape Comprehensive Heatmaps
Additional control over filtering parameters. Users can adjust different parameters to filter the heatmap data. These provide more information and control compared to the final filtered heatmaps provided on the heatmaps page.